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KMID : 1094020140310060490
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Journal of Veterinary Clinics
2014 Volume.31 No. 6 p.490 ~ p.494
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Identification of Allergens of Dermatophagoides farinae on Canine Atopic Dermatitis in Korea
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Cho Na-Young
Park Seong-Jun
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Abstract
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Dermatophagoides farinae plays important role in the pathogenesis of canine atopic dermatitis asenvironmental allergens. Also, many studies revealed that D. farinae was the main causative allergen for Korean dogswith atopic dermatitis. To identify major allergens of D. farinae in Korean atopic dogs allergic to D. farinae byimmunoblot using commercial allergenic extracts, 26 dogs from two groups were enrolled in the study. Control groupconsists of 10 dogs with no clinical signs of disease and atopic group consists of 16 dogs diagnosed as atopic dermatitis. Sera from Korean dogs with atopic dermatitis showed six allergens of D. farinae extract by procedure of immunoblot. The molecular weights of identifying protein bands were 177, 109, 75, 44, 27, 15 kDa. The major allergens showingreactivity with greater than 50% of atopic dogs were detected at approximately 44, 109 and 177 kDa. Subsequentinvestigations will be carried out to verify the identity of the allergens detected in this study.
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KEYWORD
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canine atopic dermatitis, Dermatophagoides farinae, allergen, immunoblot
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